Not wanting to play, shivering, and drinking excessively. She seems so much happier in herself but until she comes off the keppra completely I wont know if it's a reversible problem. Sarolaner, one of the ingredients, is a member of the isoxazoline class. She continued to have seizures even she was on phenobarbital. Training your dog to follow basic commands builds a positive relationship with her and helps ensure her safety. Most of us dog parents use some form of heartworm prevention for our dogs. I had placed an order with Pet Meds for the prescription before I saw any of these side effects.I will be returning this medication and order Heartgard and not sure what we will do for flea and ticks, since he turns his nos Simparica Trio, e to the Nexgard and we really dont feel safe with our Grandson around the topical or collarAny suggestions? He first started with seizures and losing weight in June after giving him Simparica. My sincere sympathies to those with horrendous seizure side effects. But I have decided not to give the replacement pill today. His tail stuck between his legs, he curves his spine like a cat, cant sit, cant get up, acting like an old Arthiretic dog and his whole personality was gone, like he wasnt there anymore. Follow up: my Labradoodle visited the ER on T-Day for 2 hrs. It seems to coincide with the monthly dosage. Did you ever do an MRI or spinal tap? You keep your dog cages? Im convinced the medicine caused this and now she cant walk. Since the weather was turning cold, I stopped giving her the Simparica until spring. I just wanted them gone and for him to feel better. The following day he died. Is Simparica only available with a prescription? She has been taking the medicine since she was 6 months and she has gotten bigger so her dosage was increased. If this is a long term issue, I doubt they would be willing to cover all visits in the future. We did abx, shampoos changed food. She is more worried about excessive thirst, lip smacking and her kidneys. What are the side effects of simparica trio for dogs? Simparica has caused my 12 pound 5 year old Jack Russel Terrior mix to have leg tremors and have trouble walking, jumping, or running. And then when we finally stop for the evening - she crashes. its only been about 4 days since and its been a steady decline. my vet recommended this for both my yorkies. No running or jumping, Continuously wandering around the fence line of the back yard. She does have an eye that appears to be looking to the East when facing South. Thank you in advance. I hate that I did this to her and I hate that the Vet does not seem to care. The vet said not to give it. It is really eye-opening to see everyone's experiences. Side effects with Simparica are not common. He said it would take care of ticks and Trifexis doesn't. As I read all the comments I am so alarmed. I am a physical therapist, and acquired Sadie to serve as a Therapy Dog in our clinic. Im switching back to the old stuff. I'm so scared. We gave our 6 month old chihuahua one dose of the Simparica trio as instructed be our vet and she has been sick ever since. Currently, for Simparica, less than 0.01% of dogs taking this medication have experienced any neurologic side effects. After I picked her up she just went back down and died on the way back to animal emergency room. We will have blood work and results this evening. I'm so glad I found this forum, it confirmed my instincts that this drug is very harmful. He's experiencing auto-inmune disease symptoms and we were told he is in critical condition. Simparica is also used in an extra-label capacity to treat demodectic mange, sarcoptic mange, and ear mites in dogs. Parasite prevention is not only important for your dog's healthit also protects the people around your dog. She's not drinking water or eating all she wants to do is sleep. I notified my vet and Zoetis, the company that makes this drug. I just gave my Matty her first dose. The only thing the vet told me was that his ATL liver enzyme levels were just slightly high (170) and it wasn't a concern and we could just do another blood test at his next check-up. Vet did all kinds of tests but said it couldnt be simparica. Today shes acting better, finally, but her back legs are still collapsing and she is weak. Also - do NOT use Bravecto for females you intend to breed. Not grass grazing either. Stressing out now. This time he is having seizures. she has shaking off and on . I am currently in the same situation and we are at day 16 after giving simparica. I sadly started my beautiful dog on Simparica Trio on May 1, 2021. Our two year old dog took the same thing and thank god she has no symptoms. How is your puppy doing? He is a 6 month old Bloodhound so they are always hyper. Not known if there be permanent after-effects. I have an appointment this Wednesday but not sure if Im going to keep it if the cough will go away eventually. He had soft poop right after I give him the pill then got worse yellow diarrhea for about a week also vomiting he fine now they changed the medication. I feel so dumb for taking him off of something that we had no problems with and it worked fine, just to try something new that he didn't need. Read package insert - yes was tested on female dogs who were bred. They want to test him for the MDR gene, put him on fluids and I have to take him in tomorrow for more fluids but he is not improving. Vets at Petsmart should know better; changing vets. It is important to work with your veterinarian to ensure the best flea/tick and heartworm prevention plan for your pets specific needs. She hasnt eaten in 3 days and is unable to go up 2 simple steps. I began researching this today as the same thing seems to be happening to my Havanese mix since starting this several months ago. CET Enzymatic Oral Hygiene Chews for Dogs. The product can be purchased directly from your vet, from your vet's online pharmacy, or through an external online pharmacy with a valid prescription. I recently switched my 3.5 year old German Shepard to simparica and about 2 weeks after his first dose he had two seizures in one night and has NEVER had them before. Im throwing away the remaining 5 pills and going back to a topical medicine. Still waiting to find out of she has progressed. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water).. Is Simparica Trio killing dogs? GAGA-gated channels help to calm nerve transmissions, which sarolaner alters, creating an influx of nerve transmissions. I have noticed that he hardly needs no meds for this neurological issue near the end of the month. She falls when she runs and when going up and down stairs. This stuff should be banned. As I said, the first was a week after taking it, then the 2nd and third seizure happened at day 29. So sorry you are having to go through this! Simparica is available in different doses for dogs 2.8 pounds and over, but has not been evaluated for use in pregnant, breeding or nursing pets. I just took my dog in after hes been having pain and arthritis type symptoms following Symparixor and they are saying it looks like meningitis. They got him to eat a little the next morning and sent him home. My poor baby! I also changed him over to a raw diet a few weeks ago too have taken him off of this again to see if raw diet is causing it. His skin became itchy and his eyes were too. I'm besides myself. I have paid about $500 - $600 to heal the little King, but it's not working. I finally got him to eat some chicken and he threw that up 2 hours later. Sarolanerstarts fighting fleas within three hours and begins to kill ticks after 8 hoursincluding the lone star tick, black-legged tick, brown dog tick, American dog tick, and Gulf Coast tick. Has there been any improvement if so how long after did it take ? Simparica Trio also prevents heartworms and keeps hookworms and roundworms from harming your pup. It may be that he is getting older as he is now one years old and he was neutered about three months ago. Strictly natural with zero side effects from now on. The only thought in my head was to get home and give it to my puppy who has had few fleas, but many itching problems. Can you tell me if your dog is back to normal now?!?! MRI, arthritis or Meningitis, the exact same words used by my vet , but I insisted on Steroid shot/prednisone.it has helped! Will NEVER give this to my dog again. Anyway, he prescribed him pain relief for 7 days. The FDA considers this level to be "very rare". Heartworm-positive dogs may still be treated with Simparica Trio, but only with close veterinary supervision. She didn't make it to the next day and died overnight. I dont want to have to put my dog down but hes suffering. One has done great only notice that he is drinking a lot of water. He also lashes at me with his teeth. Will it get worse Will he get better? I feel horrible for listening to the vet without researching this on my own. She seems more anxious now and really attached to hubby. I would, still boil chicken, carrots, potatoes for his meals. He also got that odd cough here and there that I read someone else mention. She spent 4 nights at the University of Auburn emergency room and vet clinic. Kind of ooze. Has started to stumble and sleeps 10 to 12 hours at a time. It definitely can cross blood brain barrier and cause other neurological issues so it makes sense it could do this too, but clearly they havent done enough research to understand how. But he still is suffering from lethargy, polyuria and polydispia basically still drinks and pees non stop. She has been taking Trifexis for years with no problem. I will never use this product again!!!!! He had ONE dose that evening and completely lost his appetite within a couple days. So bad that the FDA made them put a huge warning now on the package. They gave him IV glucose to raise his Potassium level. I am also going to contact the vet who gave it to me and tell him all this stuff. Ive spent over $3,000 on vet bills for at least four visits to the ER and follow up lab work including X-rays. I am up writing this 4 a.m. since our Lambchop is too restless to sleep! She is lethargic, unsteady on her feet, doesnt bark at all, showing signs of dimentia. Thank you for giving information on what happened to your dog. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. Hi, we did a spinal tap and MRI, its not viral or bacterial, its called steroid responsive meningitis which essentially is the meninges inflaming on their own, but if you look in this thread youll see others reporting similar symptoms/diagnosis so I do think Simparica trio triggered/caused it. thank you. I just gave him heartgard and nexgard about 2 weeks with no issues. My dog is currently in an emergency hospital in Chicago with my daughter. Im still confused. It is Now 3 pm and Lily is on her way to the animal hospital and most likely going to have to spend the night, we will flush her with iv and hope It helps Flush It out Of her system. There is a possibility it isn't the cause, but it is the only reason I can find and it aligns with the stories of others. 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